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#quartz crystal microbalance with dissipation monitoring (QCM-D)

The Principles of QCM-I (QCM-D) - Figure 1

The Principles of QCM-I

Quartz Crystal Microbalance with Impedance Analysis (QCM-I) and Dissipation Monitoring (QCM-D) The Quartz Crystal Microbalance is a well-established and sensitive technique used to measure the interactions of molecules, polymers and biological assemblies with a sensor surface, in air or liquid, label-free and in real time. It is based on the change in resonant frequency of […]

Variations in Coupled Water, Viscoelastic Properties, and Film Thickness of a Mefp-1 Protein Film during Adsorption and Cross-Linking:  A Quartz Crystal Microbalance with Dissipation Monitoring, Ellipsometry, and Surface Plasmon Resonance Study

Abstract We have measured the time-resolved adsorption kinetics of the mussel adhesive protein (Mefp-1) on a nonpolar, methyl-terminated (thiolated) gold surface, using three independent techniques:  quartz crystal microbalance with dissipation monitoring (QCM-D), surface plasmon resonance, and ellipsometry. The QCM-D and ellipsometry data shows that, after adsorption to saturation of Mefp-1, cross-linking of the protein layer […]

Using Complementary Acoustic and Optical Techniques for Quantitative Monitoring of Biomolecular Adsorption at Interfaces

Abstract The great wealth of different surface sensitive techniques used in biosensing, most of which claim to measure adsorbed mass, can at first glance look unnecessary. However, with each technique relying on a different transducer principle there is something to be gained from a comparison. In this tutorial review, different optical and acoustic evanescent techniques […]